KCNK6 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7886876

Der Kaninchen Polyklonal anti-KCNK6 Antikörper wird verwendet zum Nachweis von KCNK6 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für KCNK6 Antikörper (C-Term, Intracellular) (ABIN7886876)

Target: KCNK6 (Potassium Channel Subfamily K Member 6 (KCNK6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNK6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KCNK6 Antikörper

Bindungsspezifität: AA 295-313, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to KCNK6 Channel

Kreuzreaktivität: Human, Ratte

Homologie: Rat - 13,17 amino acid residues identical

Produktmerkmale: Anti-KCNK6 Antibody (ABIN7043447 and ABIN7044950) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize KCNK6 from rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)ESHQQLSASSHTDYASIPR, corresponding to residues 295-313 of human KCNK6 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236299)

Blocking Peptide: (ABIN7236299)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu KCNK6

Target: KCNK6 (Potassium Channel Subfamily K Member 6 (KCNK6))

Andere Bezeichnung: KCNK6

Hintergrund:

Synonyms: Potassium channel subfamily K member 6, TOSS, K2P6.1

Description: KCNK6 (also named Tandem of P domain of Weak Inward rectifier K+ channel 2, TWIK-2 or K2P6.1) is a member of the 2-pore (2P) domain K+ channel family that includes at least 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C- termini. The functional channel is believed to be a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH , mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators.KCNK6 displays low single channel conductance of about 5pS and is partially activated by arachidonic acid and blocked by volatile anesthetics.KCNK6 expression is widespread, especially in the rat were it is expressed in brain, heart, kidney and liver. In humans KCNK6 expression is more restricted with expression in aorta, stomach, placenta and spleen while in mouse, KCNK6 expression has been detected only in liver.

Gen-ID: 9424

NCBI Accession: NM_004823

UniProt: Q9Y257