KCNK6 Antikörper (Intracellular)

Produktnummer ABIN7043447

Produktdetails anti-KCNK6 Antikörper

Target: KCNK6 (Potassium Channel Subfamily K Member 6 (KCNK6))

Bindungsspezifität: AA 295-313, Intracellular

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNK6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: A Rabbit Polyclonal Antibody to KCNK6 Channel

Spezifität: Intracellular, C-terminus

Kreuzreaktivität: Human, Ratte

Homologie: Rat - 13,17 amino acid residues identical

Produktmerkmale: Anti-KCNK6 (TWIK-2) Antibody (ABIN7043447 and ABIN7044950)) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize KCNK6 from rat and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)ESHQQLSASSHTDYASIPR, corresponding to residues 295-313 of human KCNK6 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Kommentare:

Negative Control: BLP-PC040

Blocking Peptide: BLP-PC040

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu KCNK6

Target: KCNK6 (Potassium Channel Subfamily K Member 6 (KCNK6))

Andere Bezeichnung: KCNK6 (KCNK6 Produkte)

Hintergrund: Potassium channel subfamily K member 6, TOSS, K2P6.1,KCNK6 (also named Tandem of P domain of Weak Inward rectifier K+ channel 2, TWIK-2 or K2P6.1) is a member of the 2-pore (2P) domain K+ channel family that includes at least 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation.The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C- termini. The functional channel is believed to be a dimer.K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH , mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators.KCNK6 displays low single channel conductance of about 5pS and is partially activated by arachidonic acid and blocked by volatile anesthetics.KCNK6 expression is widespread, especially in the rat were it is expressed in brain, heart, kidney and liver. In humans KCNK6 expression is more restricted with expression in aorta, stomach, placenta and spleen while in mouse, KCNK6 expression has been detected only in liver.

Alternative names: KCNK6 (TWIK-2), Potassium channel subfamily K member 6, TOSS, K2P6.1

Gen-ID: 9424

NCBI Accession: NM_004823

UniProt: Q9Y257