P2RY2 Antikörper (Extracellular)

Produktnummer ABIN7043424

Produktdetails anti-P2RY2 Antikörper

Target: P2RY2 (Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2))

Bindungsspezifität: AA 11-24, Extracellular

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser P2RY2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI), Immunochromatography (IC)

Verwendungszweck: A Rabbit Polyclonal Antibody to P2Y2 Receptor

Spezifität: Extracellular, C-terminus

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat, human - 13,mouse - 14,15 amino acid residues identical

Produktmerkmale: Anti-P2Y2 Receptor (extracellular) Antibody (ABIN7043424, ABIN7045138 and ABIN7045139) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, live cell imaging, and immunohistochemistry applications. It has been designed to recognize P2RY2 from rat, mouse, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (CD)TINGTWEGDELGYK, corresponding to amino acid residues 11- 24 of rat P2RY2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200

Application Dilutions Western blot wb: 1:200

Kommentare:

Cited Application: ICC

Negative Control: (ABIN7236218)

Blocking Peptide: (ABIN7236218)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu P2RY2

Target: P2RY2 (Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2))

Andere Bezeichnung: P2RY2 (P2RY2 Produkte)

Hintergrund: P2Y purinoceptor 2, P2RY2, P2U1,P2Y receptors belong to the G-protein coupled receptor superfamily. P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiological responses, among them, cardiac function, platelet aggregation and SMC proliferation1.The mammalian P2Y family currently includes eight functional receptors, P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y142-4.The P2Y2 receptor is abundantly expressed in the apical membranes of several epithelial tissues including airway5. It has become a leading target for the treatment of cystic fibrosis. Activation of P2RY2 increases Cl- efflux and mucociliary clearance, effects that might relieve symptoms of cystic fibrosis. P2Y2 agonist therapy is tested in an attempt to bypass the dysfunctioning CFTR channel. Several P2Y2 receptor agonists, especially INS37217, being evaluated as possible targets for the treatment of cystic fibrosis.6

Alternative names: P2Y2 Receptor, P2Y purinoceptor 2, P2RY2, P2U1

Gen-ID: 29597

NCBI Accession: NM_176072

UniProt: P41232

Pathways: Cellular Response to Molecule of Bacterial Origin, Smooth Muscle Cell Migration