NPY1R Antikörper (AA 237-252)

Produktnummer ABIN7043371

Produktdetails anti-NPY1R Antikörper

Target: NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

Bindungsspezifität: AA 237-252

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPY1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Verwendungszweck: A Rabbit Polyclonal Antibody to Neuropeptide Y1 Receptor

Spezifität: 3rd intracellular loop

Kreuzreaktivität: Human, Ratte

Homologie: Rat,mouse - 14,16 amino acid residues identical

Produktmerkmale: Anti-NPY1R Antibody is directed against an intracellular epitope of the human neuopeptide Y1 receptor (NPY1R). Anti-NPY1R Antibody (ABIN7043371, ABIN7044668 and ABIN7044669) can be used in western blot analysis, immunohistochemistry, and immunocytochemical applications. It has been designed to recognize NPY1R from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RLKRRNNMMDKMRDNK, corresponding to amino acid residues 237-252 of human NPY1R

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Kommentare:

Cited Application: IHC|ICC

Negative Control: (ABIN7236086)

Blocking Peptide: (ABIN7236086)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Details zu NPY1R

Target: NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

Andere Bezeichnung: NPY1R (NPY1R Produkte)

Hintergrund: Neuropeptide Y1 receptor, Neuropeptide Y receptor type 1, NPYR, NPYY1,Neuropeptide Y (NPY) is a 36-amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems.1 It belongs to the NPY family, together with the peptide YY (PYY) and the pancreatic polypeptide (PP). NPY is involved in regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction.2NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y1 (NPY1R), Y2 (NPY2R), Y4 (NPY4R), Y5 (NPY5R) and Y6 (NPY6R).2 Four of these, Y1, Y2, Y4, and Y5, are expressed in humans.2 The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Activation of these receptors by NPY produces effects on [Ca2+]i, adenylate cyclase, and a number of ion channels.3 Based on the high frequency and density of NPY receptors in steroid hormone-producing tumors, the NPY receptors might be of potential use in tumor management.2NPY1R is considered to be a postsynaptic receptor. In the CNS, NPY1Rs are concentrated in the cortical areas of the brain, cerebral cortex, olfactory nucleus, hippocampus, hypothalamic nuclei, and thalamic nuclei.4 In addition, this receptor has a bimodal role in the immune system, serving as a strong negative regulator on T cells as well as a key activator of antigen-presenting cell function.5

Alternative names: NPY1R, Neuropeptide Y1 receptor, Neuropeptide Y receptor type 1, NPYR, NPYY1

Gen-ID: 4886

NCBI Accession: NM_000909

UniProt: P25929

Pathways: Negative Regulation of Hormone Secretion, Feeding Behaviour