NPY1R Antikörper (2nd Extracellular Loop)

Produktnummer ABIN7886628

Der Kaninchen Polyklonal anti-NPY1R Antikörper wird verwendet zum Nachweis von NPY1R in Proben von Maus. Er wurde validiert für WB, IHC, IF, FACS und LCI.

Kurzübersicht für NPY1R Antikörper (2nd Extracellular Loop) (ABIN7886628)

Target: NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPY1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-NPY1R Antikörper

Bindungsspezifität: 2nd Extracellular Loop, AA 197-210

Verwendungszweck: A Rabbit Polyclonal Antibody to NPY1R

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat - identical, human - 13,14 amino acid residues identical

Produktmerkmale: Anti-NPY1R (extracellular) Antibody (ABIN7043372, ABIN7044674 and ABIN7044675) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry, and live cell flow cytometry applications. It has been designed to recognize NPY1R from mouse, rat, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CFDKFPSDSHRLSY, corresponding to amino acid residues 197-210 of mouse NPY1R

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236090)

Blocking Peptide: (ABIN7236090)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu NPY1R

Target: NPY1R (Neuropeptide Y Receptor Y1 (NPY1R))

Andere Bezeichnung: NPY1R

Hintergrund:

Synonyms: Neuropeptide Y receptor type 1, NPYR, NPYY1

Description: Neuropeptide Y1 receptor (NPY1R) is one out of four receptors (NPY1R, NPY2R, NPY4R and NPY5R) that bind neuropeptide Y (NPY), an abundant neuropeptide in the mammalian central and peripheral nervous systems.NPY1R is part of the β-branch of class A G-protein coupled receptors and likewise, has seven transmembrane domains with an extracellular N-terminus and intracellular C-terminal tail1,2.NPY belongs to a family of gut-brain peptides that demonstrate both hormonal functions by paracrine and endocrine release in the gastrointestinal tract and a neurotransmitter functions in sympathetic ganglia and the CNS. It is highly expressed throughout the brain with particularly high expression in limbic brain areas, such as the hippocampus, amygdala, and hypothalamus3,4. NPY modulates multiple physiological and pathophysiological processes: it increases food intake and reduces fear and anxiety by activating NPY1R1,2.Because of the multiple functions of NPY, NPY1R has great importance in the development and progression of both metabolic and neurological diseases such as diabetes, obesity, breast cancer and bone loss and indeed a number of peptides and small-molecule compounds have been characterized as NPY1R antagonists and have shown clinical potential in the treatment of these pathological states5.

Gen-ID: 18166

NCBI Accession: NM_000909

UniProt: Q04573

Pathways: Negative Regulation of Hormone Secretion, Feeding Behaviour