NMUR2 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7886650

Der Kaninchen Polyklonal anti-NMUR2 Antikörper wird verwendet zum Nachweis von NMUR2 in Proben von Ratte. Er wurde validiert für WB, IHC, IC, IF und LCI.

Kurzübersicht für NMUR2 Antikörper (Extracellular, N-Term) (ABIN7886650)

Target: NMUR2 (Neuromedin U Receptor 2 (NMUR2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NMUR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC), Immunofluorescence (IF), Live Cell Imaging (LCI)

Produktdetails anti-NMUR2 Antikörper

Bindungsspezifität: AA 3-16, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Neuromedin-U Receptor 2

Kreuzreaktivität: Human, Maus, Ratte

Homologie: 14 amino acid residues identical,Mouse -13, human - 7

Produktmerkmale: Anti-NMUR2 (extracellular) Antibody (ABIN7043366, ABIN7044706 and ABIN7044707) is a highly specific antibody directed against an epitope of the rat Neuromedin-U receptor 2. The antibody can be used in western blot and live cell imaging applications. It has been designed to recognize NMUR2 from rat, human, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KLENASWIHDPLMK, corresponding to amino acid residues 3-16 of rat NMUR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236067)

Blocking Peptide: (ABIN7236067)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu NMUR2

Target: NMUR2 (Neuromedin U Receptor 2 (NMUR2))

Andere Bezeichnung: NMUR2

Hintergrund:

Synonyms: Neuromedin-U receptor 2, NMU2 Receptor, G-protein coupled receptor TGR-1, G-protein coupled receptor FM-4, TGR1, GPR-FM4, SNORF72

Description: Neuromedin U (NMU) is a highly conserved, ubiquitously distributed neuropeptide, which regulates food intake and body weight. Two high-affinity receptors have been identified for NMU: Neuromedin U receptor 1 (NMUR1) and Neuromedin U receptor 2 (NMUR2) that belong to the G-protein coupled receptors (GPCRs). These receptors are members of the rhodopsin-like class A GPCR family and share about 50 % identity with each other in the seven transmembrane region.NMUR2 is highly expressed in the central nervous system, in the paraventricular nucleus of the hypothalamus, nuclei accumbens, hippocampus, thalamus, medulla oblongata, and spinal cord. It is also detected in organs such as the uterus and ovary, and is abundant in nociceptive sensory pathways, including spinal dorsal horn, dorsal root ganglia, thalamus, and brain stem1-5.Central effects of NMU, including the regulation of food intake, energy balance, stress response, and nociception, are mediated by NMUR2. In the brain, NMUR2 is predominant in the hypothalamic regions that are associated with regulation of food intake and energy balance5. NMUR2 has been suggested as a potential target for developing new therapeutics for the treatment of eating disorders, obesity, stress-related disorders, and pain5.Some studies have demonstrated that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods2.

Gen-ID: 64042

NCBI Accession: NM_020167

UniProt: Q9ESQ4

Pathways: Feeding Behaviour