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HOMER1 Antikörper (Intracellular)

HOMER1 Reaktivität: Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7043273
  • Target Alle HOMER1 Antikörper anzeigen
    HOMER1 (Homer Homolog 1 (HOMER1))
    Bindungsspezifität
    • 12
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 293-296, Intracellular
    Reaktivität
    • 38
    • 19
    • 9
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 34
    • 6
    • 1
    Kaninchen
    Klonalität
    • 36
    • 5
    Polyklonal
    Konjugat
    • 27
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HOMER1 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 13
    • 12
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Verwendungszweck
    A Rabbit Polyclonal Antibody to Homer1
    Spezifität
    Intracellular
    Kreuzreaktivität
    Human, Maus, Ratte
    Kreuzreaktivität (Details)
    The antibody will not recognize Homer1 short isoform 3 (also known as Homer1a), but will recognize isoform 2 (also known as Homer1b).
    Homologie
    Mouse,human - identical
    Produktmerkmale
    Anti-Homer1 Antibody (ABIN7043273, ABIN7045168 and ABIN7045169) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Homer1 from human, mouse, and rat samples. The antibody will not recognize Homer1 short isoform 3 (also known as Homer1a), but will recognize isoform 2 (also known as Homer1b).
    Aufreinigung
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)KQEIDNARELQEQR, corresponding to amino acid residues 293-296 of rat Homer1

    Isotyp
    IgG
    Top Product
    Discover our top product HOMER1 Primärantikörper
  • Applikationshinweise

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400

    Application Dilutions Western blot wb: 1:500

    Kommentare

    Negative Control: (ABIN7235762)

    Blocking Peptide: (ABIN7235762)

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    HOMER1 (Homer Homolog 1 (HOMER1))
    Andere Bezeichnung
    HOMER1 (HOMER1 Produkte)
    Hintergrund
    Homer protein homolog 1, Homer scaffolding protein 1, Vesl-1, Ves 1, PSD-Zip45, SYN47,Homer proteins regulate signal transduction, generation of synapses and receptor trafficking. The homer protein family is comprised of three members with each member alternatively spliced to long and short forms. All members of the Homer family are synaptic scaffolding proteins with an N-terminal EVH (Ena/VASP homology 1) and a C-terminal coiled-coil domain. Long forms of the protein contain both EVH1 and coiled-coil domains and are constitutively expressed, whereas the short forms contain only the EVH1 domain and are expressed in an activity dependent manner1.The long form of Homer1 assembles group 1 metabotropic glutamate receptors mGluR1 and mGluR5 in large macromolecular complexes at synapses as well as with components of the NMDA receptor complex at the neuronal cell membrane. In contrast, the short form of Homer1 lacks the ability of linking mGluR1/5 to synaptic proteins and functions as an endogenous negative modulator of the mGluR1/5-inositol 1,4,5-trisphosphate receptor signaling complex. Transgenic mice with overexpressed Homer1 in striatal medium spiny neurons demonstrate normal development of striatal structure and afferent/efferent connectivity. However, motor performance in behavioral tasks and striatal responses to the psychomotor stimulant amphetamine are significantly altered in these mice2.At concentrations

    Alternative names: Homer1, Homer protein homolog 1, Homer scaffolding protein 1, Vesl-1, Ves 1, PSD-Zip45, SYN47
    Gen-ID
    29546
    NCBI Accession
    NM_004272
    UniProt
    Q9Z214
    Pathways
    Skeletal Muscle Fiber Development
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