Metabotropic Glutamate Receptor 3 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7886375

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Metabotropic Glutamate Receptor 3 in WB, IHC, IF, IC und LCI. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für Metabotropic Glutamate Receptor 3 Antikörper (Extracellular, N-Term) (ABIN7886375)

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Güteklasse: KO Validated

Produktdetails anti-Metabotropic Glutamate Receptor 3 Antikörper

Bindungsspezifität: Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 3

Kreuzreaktivität: Maus, Ratte

Homologie: Mouse - identical, human,monkey - 14,15 amino residues identical

Produktmerkmale: Anti-mGluR3 (extracellular) Antibody is directed against an extracellular epitope of rat mGluR3. The epitope is specific for mGluR3 and will not cross-react with the closely related mGluR2. Anti-mGluR3 (extracellular) Antibody (ABIN7043248, ABIN7044342 and ABIN7044343) can be used in western blot, live cell imaging and immunohistochemistry applications. It has been designed to recognize mGluR3 from rat and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)GDHNFMRREIKIEGD, corresponding to amino acids 24-38 of rat mGluR3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:600

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IFC

Negative Control: (ABIN7235689)

Blocking Peptide: (ABIN7235689)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Metabotropic Glutamate Receptor 3

Target: Metabotropic Glutamate Receptor 3 (GRM3) (Glutamate Receptor, Metabotropic 3 (GRM3))

Andere Bezeichnung: GRM3

Hintergrund:

Synonyms: Metabotropic glutamate receptor 3, GRM3, mGlu3, GPRC1C

Description: L-glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptor family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors. The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus that contains the glutamate binding site, and an intracellular C-terminus.1,2 mGluR2 and mGluR3 are coupled to Gi/G0 and hence inhibit cAMP formation following receptor activation.1,2mGluR3 is expressed in neurons and glia in many brain regions including the cerebral cortex, hippocampus and brain stem. mGluR3 expression is predominantly presynaptic consistent with its role as an inhibitory autoreceptor, that is, activation of mGluR3 by glutamate inhibits additional glutamate release from the same neurons.1,2Several lines of evidence suggest that mGluR3 is important for long term depression, glial function and neuroprotection. Some studies, though not all, have shown a genetic association of mGluR3 gene polymorphisms with psychosis and with schizophrenia-related phenotypes. Based in these findings, mGluR3 has been suggested as a therapeutic target for both psychosis and schizophrenia.3

Gen-ID: 24416

NCBI Accession: NM_000840

UniProt: P31422

Pathways: cAMP Metabolic Process, Synaptic Membrane