GLP2R Antikörper (1st Extracellular Loop)

Produktnummer ABIN7886417

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GLP2R in WB, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Ratte.

Kurzübersicht für GLP2R Antikörper (1st Extracellular Loop) (ABIN7886417)

Target: GLP2R (Glucagon-Like Peptide 2 Receptor (GLP2R))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLP2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-GLP2R Antikörper

Bindungsspezifität: 1st Extracellular Loop, AA 241-255

Verwendungszweck: A Rabbit  Polyclonal Antibody to Glucagon-like Peptide 2 Receptor

Homologie: Mouse,human - 13,15 amino acid residues identical

Produktmerkmale: Anti-GLP2R (extracellular) Antibody (ABIN7043221, ABIN7044408 and ABIN7044409) is a highly specific antibody directed against an epitpe of the rat glucagon-like peptide 2 receptor. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GLP2R from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)KRPDDESGWMSYLSE, corresponding to amino acid residues 241-255 of rat GLP2R

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IHC

Negative Control: (ABIN7235611)

Blocking Peptide: (ABIN7235611)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu GLP2R

Target: GLP2R (Glucagon-Like Peptide 2 Receptor (GLP2R))

Andere Bezeichnung: GLP2R

Hintergrund:

Synonyms: Glucagon-like peptide 2 receptor, GLP-2 receptor

Description: Glucagon like peptide-2 (GLP-2) is a 33 amino acid peptide secreted following food consumption. It is cleaved by dipeptidyl peptidase IV thereby yielding a very short half life. GLP-2 imposes most of its effect on intestinal epithelial cells where it is also be used as a therapeutic drug for gastrointestinal injuries1-3.The many actions of GLP-2 include cellular proliferation of intestinal epithelial cells, the increase of amino acid and lipid absorption and increase of digestive enzyme activity of the epithelial brush border cells1.The GLP-2 cellular and physiological effects are primarily exerted through the glucagon-like peptide-2 receptor (GLP-2R), a member of the G-protein coupled receptor superfamily. The receptor can couple either Gs or Gi G-proteins1. However, when heterologously expressed, the receptor can stimulate the synthesis of cAMP3.Expression of GLP-2R is strongly detected in the central nervous system and the gastrointestinal tract, although its expression in this area remains controversial as some species express the receptor in different regions than others. It is also slightly detected in the lungs, cervix and vagal afferents1.

Gen-ID: 60432

NCBI Accession: NM_004246

UniProt: Q9Z0W0

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Feeding Behaviour