GFRA3 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7886746

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GFRA3 in WB. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für GFRA3 Antikörper (Extracellular, N-Term) (ABIN7886746)

Target: GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFRA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GFRA3 Antikörper

Bindungsspezifität: AA 172-185, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to GDNF Family Receptor α3

Kreuzreaktivität: Maus, Ratte

Homologie: Mouse,rat,human - 13,14 amino acid residues identical

Produktmerkmale: Anti-GFR alpha 3 (extracellular) Antibody (ABIN7043212, ABIN7044779 and ABIN7044780) is a highly specific antibody directed against an epitope of mouse GDNF receptor α3. The antibody can be used in western blot analysis. It has been designed to recognize GFR α3 from human, mouse, and rat samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: CDRLRKAYGEA(S)SG, corresponding to amino acid residues 172-185 of mouse GFRA3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235580)

Blocking Peptide: (ABIN7235580)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu GFRA3

Target: GFRA3 (GDNF Family Receptor alpha 3 (GFRA3))

Andere Bezeichnung: GFRA3

Hintergrund:

Synonyms: GFRA3, GFRα3, GDNF family receptor α3, GDNF receptor alpha 3

Description: GFRα3 (GDNF Family Receptor α3) belongs to the glial cell line derived neurotrophic factor (GDNF) family of receptors which contains four members GFRα1-4. The GDNF family of ligands (GFLs)- GDNF, Neurturin, Artemin, and Persephin bind to co-receptors GFRα1-4 and activate Ret receptor tyrosine kinase. GDNF-family receptor α is glycosyl-phosphatidylinositol anchored to the cell surface. GFRα3 structure contains three homologous domains (D1, D2 and D3) and a C-terminal extension1-4.GFRα3 is a highly selective receptor for Artemin (Artn). Artemin is a vasculature-derived neurotrophic factor that modulates the development and function of sensory neurons and participates in the pathophysiology of peripheral inflammation and pain hyperalgesia.In adults, GFRα3 is restricted to neurons of the peripheral nervous system. The protein is expressed by a subpopulation of nociceptive sensory neurons which also express the Ret receptor tyrosine kinase, TRPV1, TRPA11,2,3.

Gen-ID: 14587

NCBI Accession: NM_001496

UniProt: O35118