GJD2 Antikörper (Intracellular)

Produktnummer ABIN7886194

Der Kaninchen Polyklonal anti-GJD2 Antikörper (ABIN7886194) detektiert spezifisch GJD2 in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für GJD2 Antikörper (Intracellular) (ABIN7886194)

Target: GJD2 (Gap Junction Protein, delta 2, 36kDa (GJD2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GJD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-GJD2 Antikörper

Bindungsspezifität: AA 170-182, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Connexin-36

Kreuzreaktivität: Maus, Ratte

Homologie: Mouse,human - 12,13 amino acid residues identical

Produktmerkmale: Anti-Connexin-36 Antibody (ABIN7043205, ABIN7044087 and ABIN7044088) is a highly specific antibody targeted against an epiotpe of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Cx36 from human, rat, and mouse samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)EVKELAPHPSGLR, corresponding to amino acid residues 170-182 of rat Connexin-36

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235554)

Blocking Peptide: (ABIN7235554)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu GJD2

Target: GJD2 (Gap Junction Protein, delta 2, 36kDa (GJD2))

Andere Bezeichnung: GJD2

Hintergrund:

Synonyms: CX36, Gap junction δ2 protein, Gap junction α9 protein, GJD2, GJA9

Description: The structural unit of the gap junctions is the connexon. Connexons are hexameric structures, formed by transcellular channels composed of connexins. Connexins (Cx) share a common structural basis, which is a four-transmembrane spanning protein, a cytoplasmic loop, two extracellular loops (E1-E2), one intracellular amino-(NT domain) and a carboxy-terminal (CT domain) region1.Connexin 36 (Cx36) is predominantly expressed in mammalian neuronal cells2. Cx36 is expressed in a variety of mammalian brain regions, but expression is particularly notable in the inferior olive, cerebellar cortex, olfactory bulbs, several brainstem nuclei, the CA3 subregion of the hippocampus and reticular thalamic nuclei3. Outside of the central nervous system, Cx36 also appears in motoneurons of adult rat spinal cord 4.Studies have shown that Cx36 is involved in some neural functions, including neuronal neurogenesis, neural fertility control and regulation of waking and sleep states, and also Cx36 plays an important role in N-methyl-D-aspartate-mediated neuronal death following neuronal injury5. A number of studies performed in humans and animals have confirmed the role of Cx36 in the generation and maintenance of seizure activity6.

Gen-ID: 50564

NCBI Accession: NM_020660

UniProt: O70610