Ephrin A5 Antikörper (Extracellular)

Produktnummer ABIN7886305

Der Kaninchen Polyklonal anti-Ephrin A5 Antikörper (ABIN7886305) detektiert spezifisch Ephrin A5 in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Ephrin A5 Antikörper (Extracellular) (ABIN7886305)

Target: Ephrin A5 (EFNA5)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ephrin A5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Ephrin A5 Antikörper

Bindungsspezifität: AA 172-186, Extracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Ephrin A5

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,rat - identical

Produktmerkmale: Anti-Ephrin-A5 (extracellular) Antibody (ABIN7043130, ABIN7044259 and ABIN7044260) is a highly specific antibody directed against an epitope of human EFNA5. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize EFNA5 from rat, mouse, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DRVFDVNDKVENSLE, corresponding to amino acid residues 172-186 of human Ephrin-A5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7235310)

Blocking Peptide: (ABIN7235310)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu Ephrin A5

Target: Ephrin A5 (EFNA5)

Andere Bezeichnung: EFNA5

Hintergrund:

Synonyms: EPH-related receptor tyrosine kinase ligand 7, LERK7, AL-1, EFNA5

Description: The Eph family of tyrosine kinase receptor signaling pathway is important for a variety of physiological processes during development including cell morphology, proliferation, migration and axonal guidance, dendritic spine formation and neural plasticity. Eph receptors mediate forward signaling in one cell while ephrin ligands transmit reverse signaling in an adjacent cell1-3.Eph receptors consist of two large subfamilies: EphA and EphB that bind to either glycophosphatidylinositol (GPI)-anchored ephrin-A ligands or transmembrane ephrin-B ligands respectively. Ephrin ligands are divided into ephrin-A (1 to 5) and ephrin-B (1 to 3)1,2.Ephrin-A5 is predominantly expressed in the quiescent anterior lens epithelial cells and is highly expressed in different layers of the cortex2,3.Studies show that mutations in ephrin-A5 are linked to congenital and age-related cataracts in humans and mice. Loss of ephrin-A5 causes abnormal localization of E-cadherin and β-catenin in anterior epithelial cells and epithelial-mesenchymal-transition2.

Gen-ID: 1946

NCBI Accession: NM_001962

UniProt: P52803

Pathways: RTK Signalweg