CALHM1 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7043013

Der Kaninchen Polyklonal anti-CALHM1 Antikörper (ABIN7043013) detektiert spezifisch CALHM1 in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für CALHM1 Antikörper (C-Term, Intracellular) (ABIN7043013)

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CALHM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-CALHM1 Antikörper

Bindungsspezifität: AA 252-265, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Calcium Homeostasis Modulator 1

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rat,mouse - identical

Produktmerkmale: Anti-CALHM1 Antibody (ABIN7043013, ABIN7044044 and ABIN7044045) is a highly specific antibody directed against an epitope of the human calcium homeostasis modulator protein 1. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CALHM1 from rat, mouse and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)EAMNHDLELGHTHG, corresponding to amino acid residues 252-265 of human CALHM1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Cited Application: IHC

Negative Control: (ABIN7235005)

Blocking Peptide: (ABIN7235005)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu CALHM1

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Andere Bezeichnung: CALHM1

Hintergrund:

Synonyms: Calcium homeostasis modulator 1, FAM26C

Description: A misbalance in Ca2+ homeostasis seems to be related to the development of Alzheimer's disease (AD). Indeed, neuronal Ca2+ balance may affect the levels of proteins associated with AD, such as amyloid-beta (Ab) and tau1.Calcium homeostasis modulator 1 (CALHM1) is a cerebral Ca2+ channel component responsible for controlling intracellular Ca2+ levels and Ab metabolism2,3. CALHM1 is a three transmembrane glycoprotein, mostly localized to the endoplasmic reticulum although it can be detected at the plasma membrane. A functional channel is formed by multiple subunits which has some structural similarities to the NMDA receptor. It is expressed in all brain regions1.In cultured cells, overexpression of CALHM1 increases intracellular Ca2+ levels and reduces Ab accumulation, thereby reinforcing its implication in the development of AD. Indeed, a polymorphism in the gene was found to affect the onset of AD2.

Gen-ID: 255022

NCBI Accession: NM_001001412

UniProt: Q8IU99