CALHM1 Antikörper (N-Term)

Produktnummer ABIN499519

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CALHM1 in WB, IF, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für CALHM1 Antikörper (N-Term) (ABIN499519)

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CALHM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-CALHM1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the amino terminus of Human CALHM1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CALHM1 antibody can be used for detection of CALHM1 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CALHM1

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Andere Bezeichnung: CALHM1 / FAM26C

Hintergrund: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-b (Ab) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Ab levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.Synonyms: Calcium homeostasis modulator protein 1

Gen-ID: 255022

NCBI Accession: NP_001001412

UniProt: Q8IU99