PRKDC Antikörper (pThr2609) (Cy3)

Produktnummer ABIN703378

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PRKDC in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für PRKDC Antikörper (pThr2609) (Cy3) (ABIN703378)

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKDC Antikörper ist konjugiert mit Cy3

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-PRKDC Antikörper (Cy3)

Bindungsspezifität: pThr2609

Kreuzreaktivität: Human, Maus

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human PRKDC around the phosphorylation site of Thr2609

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PRKDC

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Andere Bezeichnung: DNA PK/PRKDC

Hintergrund:

Synonyms: DNA PKcsThr2609, PRKDCphospho T2609, DNA PKcs phospho T2609, p-DNA PKcs phospho T2609, DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, DNA-PKcs, DNPK1, p460, PRKDC, HYRC, HYRC1, Variant, DNAPK, DNAPK catalytic subunit, p350, PRKDC, Protein Kinase DNA Activated Catalytic Polypeptide, XRCC 7, XRCC7, PRKDC_HUMAN.

Background: DNA PK is the key component of the non-homologous end-joining (NHEJ) pathway of DSB repair in mammalian cells. DNA PK consists of a heterodimeric DNA-binding subunit (Ku70/80) and an approximately 465 kDa catalytic subunit (DNA PKcs). DNA PKcs is a serine/threonine protein kinase whose activity is greatly stimulated by its recruitment to DNA breaks by the Ku heterodimer.

Gen-ID: 5591

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response