FLT3 Antikörper (pTyr589, pTyr591)
Kurzübersicht für FLT3 Antikörper (pTyr589, pTyr591) (ABIN7265244)
Target
Alle FLT3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- pTyr589, pTyr591
-
Produktmerkmale
- Phosphorylated antibody
-
Aufreinigung
- Affinity purification
-
Immunogen
- A synthetic phosphorylated peptide around Y589 & Y591 of human FLT3 (NP_004110.2).
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- WB 1:500-1:2000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 1 mg/mL
-
Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
-
Andere Bezeichnung
- FLT3
-
Hintergrund
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
-
Molekulargewicht
-
Observed_MW: 113 kDa
Calculated_MW: 108 kDa/112 kDa
-
Gen-ID
- 2322
-
UniProt
- P36888
-
Pathways
- RTK Signalweg
Target
-