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ELANE Antikörper

Der Kaninchen Polyklonal Anti-ELANE-Antikörper wurde für WB validiert. Er ist geeignet, ELANE in Proben von Human und Maus zu detektieren.
Produktnummer ABIN7256532

Kurzübersicht für ELANE Antikörper (ABIN7256532)

Target

Alle ELANE Antikörper anzeigen
ELANE (Elastase, Neutrophil Expressed (ELANE))

Reaktivität

  • 72
  • 6
  • 4
  • 2
  • 1
Human, Maus

Wirt

  • 53
  • 20
  • 5
  • 1
Kaninchen

Klonalität

  • 48
  • 31
Polyklonal

Konjugat

  • 49
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser ELANE Antikörper ist unkonjugiert

Applikation

  • 38
  • 35
  • 23
  • 12
  • 11
  • 10
  • 10
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB)
  • Produktmerkmale

    Polyclonal Antibody

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant fusion protein of human ELANE (NP_001963.1).

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    ELANE (Elastase, Neutrophil Expressed (ELANE))

    Andere Bezeichnung

    ELANE

    Hintergrund

    Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.

    Molekulargewicht

    Observed_MW: 29 kDa

    Calculated_MW: 28 kDa

    Gen-ID

    1991

    UniProt

    P08246
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