RASSF1 Antikörper

Produktnummer ABIN7256220

Der Kaninchen Polyklonal anti-RASSF1 Antikörper wird verwendet zum Nachweis von RASSF1 in Proben von Human und Maus. Er wurde validiert für IF und IHC.

Kurzübersicht für RASSF1 Antikörper (ABIN7256220)

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASSF1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails anti-RASSF1 Antikörper

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human RASSF1 (NP_009113.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:100 IF 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu RASSF1

Target: RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))

Andere Bezeichnung: RASSF1

Hintergrund: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gen-ID: 11186

UniProt: Q9NS23