ERK1/2 Antikörper (pTyr205, pTyr222)

Produktnummer ABIN7250980

Dieses Anti-ERK1/2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ERK1/2 in IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für ERK1/2 Antikörper (pTyr205, pTyr222) (ABIN7250980)

Target: ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ERK1/2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 4D4

Produktdetails anti-ERK1/2 Antikörper

Bindungsspezifität: pTyr205, pTyr222

Produktmerkmale: Phosphorylated antibody

Aufreinigung: Protein A purification

Immunogen: Synthetic Peptide of Phospho-ERK 1/2 (Tyr222/205)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:100-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ERK1/2

Target: ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))

Andere Bezeichnung: ERK 1/2

Hintergrund: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1, required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

UniProt: P27361, P28482