FGFR4 Antikörper (pTyr642)

Produktnummer ABIN7250791

Der Kaninchen Polyklonal Anti-FGFR4-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, FGFR4 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für FGFR4 Antikörper (pTyr642) (ABIN7250791)

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-FGFR4 Antikörper

Bindungsspezifität: pTyr642

Produktmerkmale: Phosphorylated antibody

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human FGFR-4 around the phosphorylation site of Tyr642

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA 1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Andere Bezeichnung: FGFR4

Hintergrund: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroma. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3.

Molekulargewicht:

Observed_MW: 90 kDa

Calculated_MW: 88 kDa

UniProt: P22455

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding