ARIH1 Antikörper

Produktnummer ABIN7003436

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ARIH1 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für ARIH1 Antikörper (ABIN7003436)

Target: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARIH1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ARIH1 Antikörper

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of human ARIH1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:100, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ARIH1

Target: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Andere Bezeichnung: ARIH1

Hintergrund: ARIH1 (ariadne homolog), also known as ubiquitin conjugating enzyme E2 binding protein 1, ARI, HARI, HHARI (human homolog of Drosophila ariadne), MOP-6 (monocyte protein 6) or UBCH7BP (UBCH7 binding protein), is a 557 amino acid cytoplasmic protein. Expressed in a wide variety of tissues, ARIH1 contains two RING-type zinc fingers and one IBR (in-between RING fingers)-type domain. ARIH1 is believed to be involved in protein degradation and protein translation. ARIH1 interacts with UBCH7 and is thought to function as an E3 ubiquitin-protein ligase (or as a component of an E3 complex) that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme (UBCH7) and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, ARIH1 interacts with and polyubiquitylates eIF4E2, thereby targeting it for proteasomal degradation.

UniProt: Q9Y4X5