HSPB8
Reaktivität: Human
WB, IHC, IF, ICC, IP
Wirt: Kaninchen
Polyclonal
Atto 594
Applikationshinweise
IHC 1:50-1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.3 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Target
HSPB8
(Heat Shock 22kDa Protein 8 (HSPB8))
Andere Bezeichnung
Crystallin-alpha C
Hintergrund
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.