CD276 Antikörper (Extracellular Domain)

Produktnummer ABIN6992267

Der Maus Monoklonal Anti-CD276-Antikörper wurde für WB, ELISA, FACS, IHC (p), ICC und IF validiert. Er ist geeignet, CD276 in Proben von Human zu detektieren.

Kurzübersicht für CD276 Antikörper (Extracellular Domain) (ABIN6992267)

Target: CD276

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD276 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: 2H5

Produktdetails anti-CD276 Antikörper

Bindungsspezifität: Extracellular Domain

Aufreinigung: B7-H3 Antibody is supplied as protein A purified IgG1.

Immunogen: B7-H3 antibody was raised against the extracellular domain of human B7-H3

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: B7-H3 antibody can be used for detection of B7-H3 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL and Immunocytochemistry starting at 1 μ,g/mL. For immunofluorescence start at 10 μ,g/mL. Flow cytometry at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples, Immunocytochemistry in human samples, Immunofluorescence in human samples and Flow Cytometry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: B7-H3 Antibody is supplied in PBS containing 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: B7-H3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CD276

Target: CD276

Andere Bezeichnung: B7H3

Hintergrund: CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 Molecules (1). CD276 mRNA is widely expressed, but its protein expression is usually rather low (2). CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3). In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4). It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.

Molekulargewicht: Predicted: 57 kDa

Observed: 100 kDa

Gen-ID: 80381

NCBI Accession: NP_001019907

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints