LAG3 Antikörper (Extracellular Domain)

Produktnummer ABIN6992261

Der Maus-Monoklonal Anti-LAG3-Antikörper wurde für ELISA, ICC und FACS validiert. Er ist geeignet zum Nachweis von LAG3 in Proben aus Human. }

Kurzübersicht für LAG3 Antikörper (Extracellular Domain) (ABIN6992261)

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LAG3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 7A7

Produktdetails anti-LAG3 Antikörper

Bindungsspezifität: Extracellular Domain

Aufreinigung: LAG-3 Antibody is supplied as protein A purified IgG2a.

Immunogen: LAG-3 antibody was raised against the extracellular domain of human LAG-3

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: LAG-3 antibody can be used for ELISA starting at 0.25 μ,g/mL. For Immunocytochemistry start at 1 μ,g/mL. For Flow Cytometry start at 1 μ,g/mL.

Antibody validated: Immunocytochemistry in human samples, Immunofluorescence in human samples and Flow Cytometry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: LAG-3 Antibody is supplied in PBS containing 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: LAG-3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu LAG3

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Andere Bezeichnung: LAG3

Hintergrund: The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.

Gen-ID: 3902

NCBI Accession: NP_002277

UniProt: P18627

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints