IL-11 Antikörper (N-Term)

Produktnummer ABIN6992179

Produktdetails anti-IL-11 Antikörper

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Bindungsspezifität: AA 40-90, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist, this antibody will only detect the longest isoform of IL-11.

Aufreinigung: IL-11 Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-11 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-11. The immunogen is located within amino acids 40 - 90 of IL-11.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IL-11 antibody can be used for the detection of IL-11 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IL-11 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IL-11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu IL-11

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Andere Bezeichnung: IL-11 (IL11 Produkte)

Synonyme: IL11 antikoerper, AGIF antikoerper, IL-11 antikoerper, Il-11 antikoerper, interleukin 11 antikoerper, IL11 antikoerper, Il11 antikoerper

Hintergrund: Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).

Molekulargewicht: Predicted: 20 kDa

Observed: 19 kDa

Gen-ID: 3589

NCBI Accession: NP_000632

UniProt: P20809

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion