GAS6 Antikörper (N-Term)

Produktnummer ABIN6992169

Dieses Anti-GAS6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GAS6 in WB, ELISA und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für GAS6 Antikörper (N-Term) (ABIN6992169)

Target: GAS6 (Growth Arrest-Specific 6 (GAS6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GAS6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GAS6 Antikörper

Bindungsspezifität: AA 60-110, N-Term

Spezifität: GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist, this antibody will only detect the longest isoform.

Aufreinigung: GAS6 Antibody is affinity chromatography purified via peptide column.

Immunogen: GAS6 antibody was raised against a 19 amino acid peptide from near the amino terminus of human GAS6. The immunogen is located within amino acids 60 - 110 of GAS6.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: GAS6 antibody can be used for the detection of GAS6 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: GAS6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: GAS6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu GAS6

Target: GAS6 (Growth Arrest-Specific 6 (GAS6))

Andere Bezeichnung: GAS6

Hintergrund: The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla)-containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2). GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3). This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4). Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2).

Molekulargewicht: Predicted: 75 kDa

Observed: 75 kDa

Gen-ID: 2621

NCBI Accession: NP_000811

UniProt: Q14393

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response