DIS3L2 Antikörper (C-Term)

Produktnummer ABIN6992168

Der Kaninchen Polyklonal Anti-DIS3L2-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, DIS3L2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für DIS3L2 Antikörper (C-Term) (ABIN6992168)

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIS3L2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-DIS3L2 Antikörper

Bindungsspezifität: AA 720-770, C-Term

Spezifität: DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist, this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.

Aufreinigung: DIS3L2 antibody is affinity chromatography purified via peptide column.

Immunogen: DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2. The immunogen is located within amino acids 720 - 770 of DIS3L2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DIS3L2 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: DIS3L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu DIS3L2

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Andere Bezeichnung: DIS3L2

Hintergrund: The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).

Molekulargewicht: Predicted: 97 kDa

Observed: 94 kDa

Gen-ID: 129563

NCBI Accession: NP_689596

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance