JAG1 Antikörper (C-Term)

Produktnummer ABIN6992092

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch JAG1 in WB, ELISA, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für JAG1 Antikörper (C-Term) (ABIN6992092)

Target: JAG1 (Jagged 1 (JAG1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-JAG1 Antikörper

Bindungsspezifität: C-Term

Spezifität: JAG1 antibody is human, mouse and rat reactive. At least two isoforms of JAG1 are known to exist, this antibody will detect both isoforms.

Aufreinigung: JAG1 antibody is affinity chromatography purified via peptide column.

Immunogen: JAG1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAG1. The immunogen is located within the last 50 amino acids of JAG1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: JAG1 antibody can be used for detection of JAG1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: JAG1 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: JAG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu JAG1

Target: JAG1 (Jagged 1 (JAG1))

Andere Bezeichnung: JAG1

Hintergrund: The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions (1). Ligands for Notch include JAG1, JAG2 and Delta. JAG1 is one of the DSL (Delta, Serrate, Lag2) transmembrane proteins that can activate Notch. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis (1,2). JAG1 is widely expressed in adult and fetal tissues and the mutation of the JAG1 gene is associated with Familial Tetrology of Fallot (3). JAG1 expression is associated with prostate cancer metastasis and is up-regulated in cervical squamous cell carcinoma (4,5).

Molekulargewicht: Predicted: 134 kDa

Observed: 130 kDa

Gen-ID: 182

NCBI Accession: NP_000205

UniProt: P78504

Pathways: Notch Signalweg, Stem Cell Maintenance