HES5 Antikörper (N-Term)

Produktnummer ABIN6992090

Der Kaninchen Polyklonal Anti-HES5-Antikörper wurde für WB, ELISA, IHC (p) und IF validiert. Er ist geeignet, HES5 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für HES5 Antikörper (N-Term) (ABIN6992090)

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HES5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-HES5 Antikörper

Bindungsspezifität: N-Term

Spezifität: HES5 antibody is human, mouse and rat reactive. At least two isoforms of HES5 are known to exist, this antibody will detect both isoforms.

Aufreinigung: HES5 antibody is affinity chromatography purified via peptide column.

Immunogen: HES5 antibody was raised against a 19 amino acid peptide near the amino terminus of human HES5. The immunogen is located within the first 50 amino acids of HES5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: HES5 antibody can be used for detection of HES5 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: HES5 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: HES5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu HES5

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Andere Bezeichnung: HES5

Hintergrund: HES5 is a member of the HES family of transcriptional repressors, which are the mammalian homologs of the Drosophila Hairy and Enhancer of Split and contain basic Helix-loop-helix (bHLH) and Orange domains (1). The HES5 gene is a downstream target of the Notch signaling pathway and its expression is downregulated during human cartilage differentiation (2). HES5 can directly repress transcription of the E3 ligase FBW7-beta, creating a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions (3).

Molekulargewicht: Predicted: 18 kDa

Observed: 17 kDa

Gen-ID: 388585

NCBI Accession: NP_001010926

UniProt: Q5TA89

Pathways: Stem Cell Maintenance, Tube Formation