IQSEC2 Antikörper (C-Term)

Produktnummer ABIN6992077

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IQSEC2 in ELISA, WB und IHC (p). Er zeigt eine Reaktivität gegenüber Maus, Human und Ratte.

Kurzübersicht für IQSEC2 Antikörper (C-Term) (ABIN6992077)

Target: IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IQSEC2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-IQSEC2 Antikörper

Bindungsspezifität: AA 1380-1430, C-Term

Spezifität: IQSEC2 antibody is human, mouse and rat reactive. At least two isoforms of IQSEC2 are known to exist, this antibody will only detect the larger isoform. IQSEC2 antibody is predicted to not cross-react with IQSEC1.

Aufreinigung: IQSEC2 antibody is affinity chromatography purified via peptide column.

Immunogen: IQSEC2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IQSEC2. The immunogen is located within amino acids 1380 - 1430 of IQSEC2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IQSEC2 antibody can be used for detection of IQSEC2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IQSEC2 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IQSEC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu IQSEC2

Target: IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))

Andere Bezeichnung: IQSEC2

Hintergrund: ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. Similar to the related protein IQSEC1, IQSEC2 is a guanine nucleotide exchange protein for ARF1 and ARF6 that belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain (1,2). IQSEC2 is a major component of the postsynaptic density (PSD) and colocalizes with PSD-95. It has been suggested to modulate the functions of the ARF proteins (1). Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation (3).

Molekulargewicht: Predicted: 104, 133, 141, 164 kDa

Observed: 140 kDa

Gen-ID: 23096

NCBI Accession: NP_001104595

UniProt: Q5JU85