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IQSEC2 Antikörper (AA 851-950) (Biotin)

IQSEC2 Reaktivität: Maus ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1700349
  • Target Alle IQSEC2 Antikörper anzeigen
    IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))
    Bindungsspezifität
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 851-950
    Reaktivität
    • 18
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 19
    • 1
    Kaninchen
    Klonalität
    • 20
    Polyklonal
    Konjugat
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IQSEC2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 13
    • 13
    • 6
    • 4
    • 4
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human IQSEC2
    Isotyp
    IgG
    Top Product
    Discover our top product IQSEC2 Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    IQSEC2 (IQ Motif and Sec7 Domain 2 (IQSEC2))
    Andere Bezeichnung
    IQSEC2 (IQSEC2 Produkte)
    Synonyme
    BRAG1 antikoerper, MRX1 antikoerper, Brag1 antikoerper, mKIAA0522 antikoerper, RGD1562109 antikoerper, IQ motif and Sec7 domain 2 antikoerper, IQSEC2 antikoerper, Iqsec2 antikoerper
    Hintergrund

    Synonyms: BRAG1, IQ mot and SEC7 domain-containing protein 2, IQEC2_HUMAN, Iqsec2, KIAA0522, mKIAA0522, MRX1, RP11-258C19.1.

    Background: IQSEC2 is a 1,478 amino acid protein that belongs to the BRAG family and contains one IQ domain, one PH domain and a SEC7 domain. Localizing to the cytoplasm, IQSEC2 is expressed in brain, kidney and small intestine, with weaker levels of expression in placenta, pancreas, ovary, prostate and liver. IQSEC2 is a component of the postsynaptic density at excitatory synapses, and interacts with ARF family members as a guanine nucleotide exchange factor. Through the activation of ARF substrates, IQSEC2 may play a crucial role in cytoskeletal and synaptic organization. The gene encoding IQSEC2 maps to the human X chromosome. Defects to the IQSEC2 gene have been linked to mental retardation X-linked type 1 (MRX1), a condition characterized by decreased intellectual function. IQSEC2 exists as three isoforms due to alternative splicing events.

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