TXNIP Antikörper (AA 110-160)
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- Target Alle TXNIP Antikörper anzeigen
- TXNIP (Thioredoxin Interacting Protein (TXNIP))
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Bindungsspezifität
- AA 110-160
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TXNIP Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Spezifität
- TXNIP antibody is human, mouse and rat reactive.
- Aufreinigung
- TXNIP antibody is affinity chromatography purified via peptide column.
- Immunogen
- TXNIP antibody was raised against a 16 amino acid peptide near the center of human TXNIP. The immunogen is located within amino acids 110 - 160 of TXNIP.
- Isotyp
- IgG
- Top Product
- Discover our top product TXNIP Primärantikörper
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- Applikationshinweise
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TXNIP body can be used for detection of TXNIP by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for Immunohistochemistry at 2 μ,g/mL. For Immunoflorescence start at 5 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- TXNIP antibody is supplied in PBS containing 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,4 °C
- Informationen zur Lagerung
- TXNIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- Target
- TXNIP (Thioredoxin Interacting Protein (TXNIP))
- Andere Bezeichnung
- TXNIP (TXNIP Produkte)
- Synonyme
- EST01027 antikoerper, HHCPA78 antikoerper, THIF antikoerper, VDUP1 antikoerper, Gm348 antikoerper, Trf3 antikoerper, TBP2 antikoerper, TRF3 antikoerper, 1200008J08Rik antikoerper, AA682105 antikoerper, Hyplip1 antikoerper, Tbp-2 antikoerper, Vdup1 antikoerper, sb:cb368 antikoerper, txnip antikoerper, thioredoxin interacting protein antikoerper, TATA box binding protein like 2 antikoerper, TATA-box binding protein like 2 antikoerper, thioredoxin interacting protein L homeolog antikoerper, thioredoxin interacting protein a antikoerper, TXNIP antikoerper, Tbpl2 antikoerper, TBPL2 antikoerper, Txnip antikoerper, txnip.L antikoerper, txnip antikoerper, txnipa antikoerper
- Hintergrund
- Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2). It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2). TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3). It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4). TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5).
- Molekulargewicht
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Predicted: 43 kDa
Observed: 39 kDa - Gen-ID
- 10628
- NCBI Accession
- NP_006463
- UniProt
- Q9H3M7
- Pathways
- Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome
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