CTNND1 Antikörper (N-Term)

Produktnummer ABIN6992002

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CTNND1 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für CTNND1 Antikörper (N-Term) (ABIN6992002)

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTNND1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CTNND1 Antikörper

Bindungsspezifität: N-Term

Spezifität: CASR antibody is human, mouse and rat reactive. At least two isoforms of CASR are known to exist.

Aufreinigung: CASR antibody is affinity chromatography purified via peptide column.

Immunogen: CASR antibody was raised against a 15 amino acid peptide near the amino terminus of human CASR. The immunogen is located within the first 50 amino acids of CASR.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CASR antibody can be used for detection of CASR by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CASR Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CASR antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CTNND1

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Andere Bezeichnung: CAS

Hintergrund: The calcium-sensing receptor protein (CASR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (1). It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis (1). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (1,2). Recent evidence suggests that activated CASR contributes to the cytokine secretion through the partial MAPK and NF-kappaB pathways in T cells (3).

Molekulargewicht: Predicted: 101, 120 kDa

Observed: 115, 125 kDa

Gen-ID: 846

NCBI Accession: NP_001171536

UniProt: P41180

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling