CXCR3 Antikörper (C-Term)

Produktnummer ABIN6991955

Der Kaninchen Polyklonal Anti-CXCR3-Antikörper wurde für WB, ELISA, ICC und IF validiert. Er ist geeignet, CXCR3 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CXCR3 Antikörper (C-Term) (ABIN6991955)

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-CXCR3 Antikörper

Bindungsspezifität: C-Term

Spezifität: CXCR3 antibody is human, mouse and rat reactive. At least two isoforms of CXCR3 are known to exist, this antibody will detect both isoforms.

Aufreinigung: CXCR3 antibody is affinity chromatography purified via peptide column.

Immunogen: CXCR3 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human CXCR3 . The immunogen is located within the last 50 amino acids of CXCR3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CXCR3 antibody can be used for detection of CXCR3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CXCR3 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CXCR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CXCR3

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Andere Bezeichnung: CXCR3

Hintergrund: The CXCR3 protein is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-gamma), CXCL10/IP10 (interferon-gamma-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell alpha-chemoattractant) (reviewed in 1). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration (2). Similar to other chemokine receptors such as CXCR4, CXCR3 has been implicated in several malignancies as a biomarker of tumor behavior as well as a potential therapeutic target (3).

Molekulargewicht: Predicted: 46 kDa

Observed: 43 kDa

Gen-ID: 2833

NCBI Accession: NP_001136269

UniProt: P49682