UNG Antikörper (C-Term)

Produktnummer ABIN6991909

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch UNG in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für UNG Antikörper (C-Term) (ABIN6991909)

Target: UNG (Uracil-DNA Glycosylase (UNG))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-UNG Antikörper

Bindungsspezifität: C-Term

Aufreinigung: UNG1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-UNG1 antibody was raised against a peptide corresponding to 13 amino acids near the carboxy terminus of human UNG1. The immunogen is located within the last 50 amino acids of UNG1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.5-4 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: UNG1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: UNG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Andere Bezeichnung: UNG1

Hintergrund: UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.

Molekulargewicht: Predicted: 34kD

Observed: 34 kD kDa

Gen-ID: 7374

NCBI Accession: NP_003353

UniProt: P13051

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response