BTLA Antikörper (AA 170-220)

Produktnummer ABIN6991902

Der Kaninchen Polyklonal anti-BTLA Antikörper (ABIN6991902) detektiert spezifisch BTLA in WB, ELISA, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für BTLA Antikörper (AA 170-220) (ABIN6991902)

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BTLA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BTLA Antikörper

Bindungsspezifität: AA 170-220

Spezifität: BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.

Aufreinigung: BTLA Antibody is affinity chromatography purified via peptide column.

Immunogen: BTLA antibody was raised against a 17 amino acid peptide near the center of human BTLA. The immunogen is located within amino acids 170 - 220 of BTLA .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: BTLA antibody can be used for detection of BTLA by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BTLA Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BTLA antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Andere Bezeichnung: BTLA

Hintergrund: The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1). Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2). Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3).

Molekulargewicht: Predicted: 32 kDa

Observed: 40kDa

Gen-ID: 151888

NCBI Accession: NP_861445

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints