ERAP1 Antikörper (C-Term)

Produktnummer ABIN6991899

Dieses Anti-ERAP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ERAP1 in WB, ELISA, IF und IHC (p). Geeignet für Human und Maus.

Kurzübersicht für ERAP1 Antikörper (C-Term) (ABIN6991899)

Target: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ERAP1 Antikörper

Bindungsspezifität: AA 730-780, C-Term

Spezifität: ERAP1 antibody is human and mouse reactive. At least two isoforms of ERAP1 are known to exist, this antibody will detect both isoforms. ERAP1 antibody is predicted to not cross-react with ERAP2.

Aufreinigung: ERAP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: ERAP1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ERAP. The immunogen is located within amino acids 730 - 780 of ERAP1 .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ERAP1 antibody can be used for detection of ERAP1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ERAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ERAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu ERAP1

Target: ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))

Andere Bezeichnung: ERAP1

Hintergrund: The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1), a member of the peptidase M1 family, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). It is also designated as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1) (3). ERAP1 is localized to the lumen of the ER and induced by interferon. It may be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (3,4).

Molekulargewicht: Predicted: 104 kDa

Observed: 105kDa

Gen-ID: 51752

NCBI Accession: NP_057526

UniProt: Q9NZ08