UNG Antikörper (N-Term)

Produktnummer ABIN6991863

Dieses Anti-UNG-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von UNG in WB, ELISA und IF. Geeignet für Human und Maus.

Kurzübersicht für UNG Antikörper (N-Term) (ABIN6991863)

Target: UNG (Uracil-DNA Glycosylase (UNG))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-UNG Antikörper

Bindungsspezifität: N-Term

Spezifität: At least two isoforms of UNG2 are known to exist, this antibody will only detect the longer isoform. UNG2 antibody is predicted to not cross-react with UNG1.

Aufreinigung: UNG2 Antibody is affinity chromatography purified via peptide column.

Immunogen: UNG2 antibody was raised against a 17 amino acid peptide near the amino terminus of human UNG2. The immunogen is located within the first 50 amino acids of UNG2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: UNG2 antibody can be used for detection of UNG2 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: UNG2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: UNG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Andere Bezeichnung: UNG2

Hintergrund: UNG2 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promoters and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome.

Molekulargewicht: Predicted: 34 kDa

Observed: 33 kDa

Gen-ID: 7374

NCBI Accession: NP_550433

UniProt: P13051

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response