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KREMEN1 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KREMEN1 in WB, ELISA, IHC (p) und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN6991831

Kurzübersicht für KREMEN1 Antikörper (C-Term) (ABIN6991831)

Target

Alle KREMEN1 Antikörper anzeigen
KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Reaktivität

  • 35
  • 7
  • 5
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 32
  • 3
  • 2
Kaninchen

Klonalität

  • 33
  • 4
Polyklonal

Konjugat

  • 22
  • 3
  • 3
  • 3
  • 3
  • 3
Dieser KREMEN1 Antikörper ist unkonjugiert

Applikation

  • 30
  • 24
  • 18
  • 8
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
  • Bindungsspezifität

    • 8
    • 8
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    Three isoforms of KREMEN1 exists as a result of alternative splicing event.

    Aufreinigung

    KREMEN1 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1. The immunogen is located within the last 50 amino acids of KREMEN1.

    Isotyp

    IgG
  • Applikationshinweise

    KREMEN1 antibody can be used for detection of KREMEN1 by Western blot at 0.125 - 0.25 μ,g/mL.

    Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    KREMEN1 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,4 °C

    Informationen zur Lagerung

    KREMEN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target

    KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

    Andere Bezeichnung

    KREMEN1

    Hintergrund

    KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.

    Molekulargewicht

    54 kDa

    Gen-ID

    83999

    NCBI Accession

    NP_114434

    UniProt

    Q96MU8

    Pathways

    WNT Signalweg
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