IL-15 Antikörper (AA 50-100)

Produktnummer ABIN6991820

Der Kaninchen Polyklonal Anti-IL-15-Antikörper wurde für WB, ELISA und IHC (p) validiert. Er ist geeignet, IL-15 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für IL-15 Antikörper (AA 50-100) (ABIN6991820)

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-IL-15 Antikörper

Bindungsspezifität: AA 50-100

Spezifität: At least two isoforms of IL-15 are known to exist.

Aufreinigung: IL-15 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal IL-15 antibody was raised against a 13 amino acid peptide near the center of human IL-15. The immunogen is located within amino acids 50 - 100 of IL-15.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IL-15 antibody can be used for detection of IL-15 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IL-15 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IL-15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu IL-15

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Andere Bezeichnung: IL-15

Hintergrund: IL-15 Antibody: Interleukin 15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.

Molekulargewicht: 18 kDa

Gen-ID: 3600

NCBI Accession: NP_000576

UniProt: P40933

Pathways: JAK-STAT Signalweg, Glycosaminoglycan Metabolic Process