TPT1 Antikörper (AA 80-130)

Produktnummer ABIN6991810

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TPT1 in WB, ELISA, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für TPT1 Antikörper (AA 80-130) (ABIN6991810)

Target: TPT1 (Tumor Protein, Translationally-Controlled 1 (TPT1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TPT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TPT1 Antikörper

Bindungsspezifität: AA 80-130

Aufreinigung: TPT1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal TPT1 antibody was raised against a 19 amino acid peptide near the center of human TPT1. The immunogen is located within amino acids 80 - 130 of TPT1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TPT1 antibody can be used for detection of TPT1 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TPT1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TPT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu TPT1

Target: TPT1 (Tumor Protein, Translationally-Controlled 1 (TPT1))

Andere Bezeichnung: TPT1

Hintergrund: TPT1 Antibody: TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.

Molekulargewicht: Predicted: 19 kDa

Gen-ID: 7178

NCBI Accession: NP_003286

UniProt: P13693

Pathways: Response to Water Deprivation, Regulation of Cell Size, Negative Regulation of intrinsic apoptotic Signaling