TYK2 Antikörper (N-Term)

Produktnummer ABIN6991802

Der Kaninchen Polyklonal Anti-TYK2-Antikörper wurde für WB, ELISA und IF validiert. Er ist geeignet, TYK2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für TYK2 Antikörper (N-Term) (ABIN6991802)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-TYK2 Antikörper

Bindungsspezifität: AA 90-140, N-Term

Spezifität: At least three isoforms of TYK2 are known to exist, this antibody only detects the two longest isoforms.

Aufreinigung: TYK2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2. The immunogen is located within amino acids 90 - 140 of TYK2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TYK2 antibody can be used for detection of TYK2 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TYK2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TYK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Andere Bezeichnung: TYK2

Hintergrund: TYK2 Antibody: TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Molekulargewicht: Predicted: 131 kDa

Gen-ID: 7297

NCBI Accession: NP_003322

UniProt: P29597

Pathways: JAK-STAT Signalweg, Hepatitis C