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Pellino 1 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-Pellino 1-Antikörper wurde für WB, ELISA, ICC und IF validiert. Er ist geeignet, Pellino 1 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN6991769

Kurzübersicht für Pellino 1 Antikörper (C-Term) (ABIN6991769)

Target

Alle Pellino 1 (PELI1) Antikörper anzeigen
Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))

Reaktivität

  • 23
  • 6
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 21
  • 2
Kaninchen

Klonalität

  • 20
  • 3
Polyklonal

Konjugat

  • 18
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Pellino 1 Antikörper ist unkonjugiert

Applikation

  • 23
  • 11
  • 6
  • 6
  • 2
  • 1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 300-350, C-Term

    Aufreinigung

    Pellino 1 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    Rabbit polyclonal Pellino 1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Pellino 1. The immunogen is located within amino acids 300 - 350 of Pellino 1.

    Isotyp

    IgG
  • Applikationshinweise

    Pellino 1 antibody can be used for detection of Pellino 1 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Pellino 1 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,4 °C

    Informationen zur Lagerung

    Pellino 1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))

    Andere Bezeichnung

    Pellino 1

    Hintergrund

    Pellino 1 Antibody: The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-κ,B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-ε, and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.

    Molekulargewicht

    46 kDa

    Gen-ID

    57162

    NCBI Accession

    NP_065702

    UniProt

    Q96FA3

    Pathways

    Activation of Innate immune Response, Toll-Like Receptors Cascades
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