FLT3 Antikörper (AA 340-390)

Produktnummer ABIN6991750

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FLT3 in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für FLT3 Antikörper (AA 340-390) (ABIN6991750)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-FLT3 Antikörper

Bindungsspezifität: AA 340-390

Spezifität: At least three isoforms of FLT3 are known to exist, this antibody will detect all isoforms.

Aufreinigung: FLT3 Antibody is affinity chromatography purified via peptide column.

Immunogen: FLT3 antibody was raised against an 18 amino acid synthetic peptide near the center of human FLT3. The immunogen is located within amino acids 340 - 390 of FLT3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FLT3 antibody can be used for detection of FLT3 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FLT3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: FLT3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Andere Bezeichnung: FLT3

Hintergrund: FLT3 Antibody: FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.

Molekulargewicht: 109 kDa

Gen-ID: 2322

NCBI Accession: NP_004110

UniProt: P36888

Pathways: RTK Signalweg