BCL6 Antikörper (AA 370-420)

Produktnummer ABIN6991734

Der Kaninchen Polyklonal anti-BCL6 Antikörper (ABIN6991734) detektiert spezifisch BCL6 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für BCL6 Antikörper (AA 370-420) (ABIN6991734)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-BCL6 Antikörper

Bindungsspezifität: AA 370-420

Spezifität: Three alternatively spliced transcript variants have been observed

Aufreinigung: BCL6 Antibody is affinity chromatography purified via peptide column.

Immunogen: BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of human BCL6. The immunogen is located within amino acids 370 - 420 of BCL6.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: BCL6 antibody can be used for detection of BCL6 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BCL6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BCL6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Andere Bezeichnung: BCL6

Hintergrund: BCL6 Antibody: BCL6 was first identified as a proto-oncogene in diffuse large B cell lymphoma. BCL6, a transcriptional repressor, plays an important role in lymphomagenesis. It binds Stat recognition-like DNA elements and is required for affinity maturation of mature B cells in germinal centers and Th1/Th2 differentiation, a process that critically depends on BCL6-mediated transcriptional repression of p53. BCL6 is a pharmacological target for eradication of leukemia-initiating cells in chronic myeloid leukemia (CML).

Molekulargewicht: 78 kDa

Gen-ID: 604

NCBI Accession: NP_001124317

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus