ZFYVE21 Antikörper (N-Term)

Produktnummer ABIN6991717

Produktdetails anti-ZFYVE21 Antikörper

Target: ZFYVE21 (Zinc Finger, FYVE Domain Containing 21 (ZFYVE21))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZFYVE21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Spezifität: At least two isoforms of ZF21 are known to exist, this antibody will detect both isoforms.

Aufreinigung: ZF21 Antibody is affinity chromatography purified via peptide column.

Immunogen: ZF21 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ZF21. The immunogen is located within the first 50 amino acids of ZF21.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ZF21 antibody can be used for detection of ZF21 by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ZF21 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ZF21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ZFYVE21

Target: ZFYVE21 (Zinc Finger, FYVE Domain Containing 21 (ZFYVE21))

Andere Bezeichnung: ZF21 (ZFYVE21 Produkte)

Hintergrund: ZF21 Antibody: ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.

Gen-ID: 79038

NCBI Accession: NP_001185882

UniProt: Q9BQ24