TTYH2 Antikörper (N-Term)

Produktnummer ABIN6991699

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TTYH2 in ELISA, WB, IHC (p) und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für TTYH2 Antikörper (N-Term) (ABIN6991699)

Target: TTYH2 (Tweety Homolog 2 (TTYH2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TTYH2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-TTYH2 Antikörper

Bindungsspezifität: AA 60-110, N-Term

Spezifität: At least four isoforms of TTYH2 are known to exist, this antibody will only detect the two longest isoforms. This antibody is predicted to not cross-react with other TTYH family members.

Aufreinigung: TTYH2 Antibody is affinity chromatography purified via peptide column.

Immunogen: TTYH2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TTYH2. The immunogen is located within amino acids 60 - 110 of TTYH2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TTYH2 antibody can be used for detection of TTYH2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TTYH2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TTYH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TTYH2

Target: TTYH2 (Tweety Homolog 2 (TTYH2))

Andere Bezeichnung: TTYH2

Hintergrund: TTYH2 Antibody: TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.

Gen-ID: 94015

NCBI Accession: NP_116035

UniProt: Q9BSA4