Nibrin Antikörper (N-Term)

Produktnummer ABIN6991690

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Nibrin in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Nibrin Antikörper (N-Term) (ABIN6991690)

Target: Nibrin (NBN)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nibrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Nibrin Antikörper

Bindungsspezifität: AA 50-100, N-Term

Spezifität: At least three alternatively spliced transcript isoforms of NIBRIN are known to exist.

Aufreinigung: NIBRIN Antibody is affinity chromatography purified via peptide column.

Immunogen: NIBRIN antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NIBRIN. The immunogen is located within amino acids 50 - 100 of NIBRIN.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NIBRIN antibody can be used for detection of NIBRIN by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NIBRIN Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: NIBRIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Nibrin

Target: Nibrin (NBN)

Andere Bezeichnung: NIBRIN

Hintergrund: NIBRIN Antibody: NIBRIN (NBN) is a member of the double-strand break repair complex MRE11/RAD50/NBN (MRN) which is involved in DNA double-strand break repair, DNA damage-induced checkpoint activation and plays a critical role in the maintenance of chromosome integrity. NIBRIN contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. Mutations in this gene are associated with Nijmegen breakage syndrome and maybe the cause of cancer predisposition and aplastic anemia.

Gen-ID: 4683

NCBI Accession: NP_002476

UniProt: O60934

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response