SYNPO2 Antikörper (N-Term)

Produktnummer ABIN6991443

Dieses Anti-SYNPO2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SYNPO2 in ELISA, WB, IF und IHC (p). Geeignet für Human und Maus.

Kurzübersicht für SYNPO2 Antikörper (N-Term) (ABIN6991443)

Target: SYNPO2 (Synaptopodin 2 (SYNPO2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYNPO2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SYNPO2 Antikörper

Bindungsspezifität: AA 320-370, N-Term

Aufreinigung: SYNPO2 Antibody is affinity chromatography purified via peptide column.

Immunogen: SYNPO2 antibody was raised against a 20 amino acid synthetic peptide near the amino terminus of human SYNPO2. The immunogen is located within amino acids 320 - 370 of SYNPO2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SYNPO2 antibody can be used for detection of SYNPO2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SYNPO2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SYNPO2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SYNPO2

Target: SYNPO2 (Synaptopodin 2 (SYNPO2))

Andere Bezeichnung: SYNPO2

Hintergrund: SYNPO2 Antibody: SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.

Gen-ID: 171024

NCBI Accession: NP_597734

UniProt: Q9UMS6