FOXO3 Antikörper (N-Term)

Produktnummer ABIN6991359

Dieses Anti-FOXO3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FOXO3 in WB, ELISA, IF und ICC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für FOXO3 Antikörper (N-Term) (ABIN6991359)

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-FOXO3 Antikörper

Bindungsspezifität: AA 40-90, N-Term

Aufreinigung: FOXO3 Antibody is affinity chromatography purified via peptide column.

Immunogen: FOXO3 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human FOXO3. The immunogen is located within amino acids 40 - 90 of FOXO3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FOXO3 antibody can be used for detection of FOXO3 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 4 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FOXO3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: FOXO3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FOXO3

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Andere Bezeichnung: FOXO3

Hintergrund: FOXO3 Antibody: FOXO3 is a ubiquitously expressed 75 kDa protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. FOXO3 is involved with mTOR in the regulation of autophagy in skeletal muscle, and activates protein degradation in atrophying muscle cells. FOXO3 has also been implicated in several neurodegenerative disorders including aging, neuromuscular disease, systemic lupus erythmatosus, stroke and diabetic complications.

Gen-ID: 2309

NCBI Accession: NP_963853

UniProt: O43524

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis